Search results for " Heroin"
showing 9 items of 9 documents
Loss of spatial learning in a patient with topographical disorientation in new environments
2003
The case is described of a patient who, following cerebral hypoxia, developed severe difficulty in orienting himself in new environments in the context of a mild global amnesic syndrome. Some episodes he related suggested that his main difficulty was remembering the spatial/directional value of landmarks he recognised. A neuroradiological examination documented severe bilateral atrophy of the hippocampi associated with atrophic changes in the cerebral hemispheres, most marked in the dorsal regions. Neuropsychological and experimental evaluation showed a severe deficit of spatial learning with substantially preserved ability to learn verbal and visual-object information. He was also virtuall…
Slow release oral morphine versus methadone for the treatment of opioid use disorder
2019
ObjectiveTo assess the efficacy of slow release oral morphine (SROM) as a treatment for opioid use disorder (OUD).DesignSystematic review and meta-analysis of randomised controlled trials (RCTs).Data sourcesThree electronic databases were searched through 1 May 2018: the Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE. We also searched the following electronic registers for ongoing trials: ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Current Controlled Trials and the EU Clinical Trials Register.Eligibility criteria for selecting studiesWe included RCTs of all durations, assessing the effect of SROM on measures of treatment retention, heroin use…
Kategoria kobiecości oczami Reymonta i Gorkiego
2015
Piccole città per quarantenni. Sul senso di sé nella scrittura storiografica, in margine a un libro di Vanessa Roghi
2019
Starting from an analysis of Vanessa Roghi's recent book, Piccole città, we focus on the link between historiographic writing and autobiography. In particular, it analyzes the way this link changed at the end of the twentieth century, when political categories that had determined identities, even of historians, for more than a century, have finished. Since then, issues considered "private" have emerged in the public debate and in the historiographic debate, as happened for example with drug addiction, at the centre of Roghi's book.
Italian Heroines: Literature, Gender, and the Construction of the Nation
2019
Scholarship on Italian nationhood has historically focused on heroes rather than on heroines, in line with the established gendered dialectical relationship between the female nation (who nurtures those who fight for her), and the male patriot, who both adores and possesses her. However, it is argued that Italian literary heroines prove at least as productive as heroes, if not more, when it comes to generating alternative views on the nation. This essay offers an introduction to a themed issue that aims to fill this scholarly gap in relation to ideas about the Italian nation and nationhood.
Methadone versus buprenorphine: data detected from Caltanissetta SER.T
2020
In last years, heroin-addicted have exponentially increased: this has made it necessary to identify a pharmacological strategy as effective as possible. With this purpose, a statistical investigation was conducted in a sample of individuals, aged between 18 and 50. They were diagnosed and subjected to different treatments at Ser.T of Caltanissetta (Sicily-Italy) during the period 2013-2017. The analyzed patients were treated with three different pharmacological therapy: methadone 0.1%, methadone 0.5%, buprenorphine and suboxone. We obtained percentages of responders, low responders and non-responders patients from data processing, based on used therapy. Considering pharmacological responses…
El tratamiento de las toxicomanías y la medicina basada en la evidencia: una alianza necesaria
2007
La medicina basada en la evidencia (MBE) se ha convertido en el nuevo paradigma de la práctica clínica. Desde su desarrollo inicial en la década de los 90 en la Universidad de Ontario y su difusión europea posterior, representa el más alto estándar de calidad en la práctica como ha sido reconocido no sólo por los clínicos y otros profesionales de la salud sino también por administraciones y otros agentes del sistema sanitario. A pesar de este papel destacado en la atención sanitaria, su penetración más allá de un reducido número de profesionales de la salud es muy limitada. La MBE tiene sus raíces en la aplicación de la mejor evidencia publicada a pacientes individuales considerando también…
Unexpected variation of the codeine/morphine ratio following fatal heroin overdose.
2014
Postmortem samples from 14 cases of suspected heroin overdose were subjected to a preliminary systematic toxicological analysis in order to highlight the presence of unknown exogenous compounds (e.g., drugs of abuse, alcohol) that may have played a role in the mechanism of death. This analysis unveiled histories of poly-drug use in seven of the cases under investigation. Moreover, the concentrations of morphine and codeine in the brain were also investigated, and the results were compared with the data obtained from the blood specimens. The concentration of morphine in blood ranged from 33 to 688 ng/mL, while the concentration of codeine ranged from 0 to 193 ng/mL. However, in the brain, th…
BRUGADA PATTERN IN HEROIN ADDICTION: SYNDROME OR PHENOCOPY?
2020
Brugada phenocopies (BrPs) are clinical entities that show an electrocardiogram (ECG) pattern similar to what is observed in Brugada syndrome (BrS). They are caused by different clinical conditions. We describe a case of BrP in a man that developed acute kidney failure secondary to rhabdomyolysis, after heroin addiction. His initial ECG showed Brugada type 1 pattern resolved after hemodialytic treatment. A provocative test with ajmaline, which resulted negative, was performed to confirm the diagnosis. BrPs can mimic a true BrS and a fast recognition of these clinical and electrocardiographic findings may avoid diagnostic mistakes thus preventing unnecessary or inaccurate treatmen